Synapses are highly specialized sites of contact consisting of a pre- and postsynaptic side. They are the fundamental units of information transfer between nerve cells. Research in our laboratory focuses on the cellular and molecular mechanisms of synaptic function. Understanding the most complex problems in synaptic biology requires multidisciplinary approaches which allow for precise quantitative measurements. To do so, we combine electrophysiological, Ca2+ imaging, biophysical and morphological methods in conjunction with molecular perturbations using recombinant viral vectors to study interactions among key synaptic proteins in modulating synaptic transmission, plasticity, development and maintenance.

Figure 1

Fig 1. EGFP positive calyces from transverse brainstem slices from p8 (postnatal day 8) Wistar rats injected with 2nd generation neurospecifc recombinant Adenoviral vectors at p1. Left panels: transillumination images. Right panel corresponding fluorescence image. Panels (A,B) 10x magnification. Panels (C,D) 60x magnification

Figure 2

Fig 2. 3D reconstruction of the calyx of Held synapse at different postnatal developmental stages

CONTACT INFO

Samuel M. Young, Jr., Ph.D
Max Planck Research Group Leader
Molecular Mechanisms of Synaptic Function
One Max Planck Way
Jupiter, FL 33458

Phone:
(561) 972-9402 (office)
(561) 972-9403 (lab)

Fax: (561) 972-9001

AVAILABLE POSITIONS

Post Doc Candidate